Elastin-like polypepxide (ELP) is a synthetic polypepxide polymer derived from natural elastin. elastin-like polypepxide (ELP) has a special temperature responsiveness, which shows a reversible phase transition in response to temperature, and this temperature-sensitive property can be fully preserved when it is coupled with other small molecules or pepxides. ELP and ELP fusion proteins can be artificially synthesised with the help of genetic engineering to precisely regulate the structure and function of ELP and to add reactive amino acids or pepxides to its sequence. Meanwhile, ELP is composed of natural amino acids, which are biocompatible, easily biodegradable, low immunogenicity and non-toxic. Based on the above advantages, ELPs have been widely used in biomedical fields such as protein expression and purification, in vitro diagnostics, drug delivery and tissue engineering.