Palmitoylethanol is produced naturally by the body and all cells can produce this substance. Its levels are higher when the body is stressed. At the same time, palmitoylethanol is found in a variety of foods, such as egg yolks, peanuts soy lecithin, soya beans, lentils, peas, tomatoes, corn, milk.
Applications
Palmitoylethanol is a naturally occurring fatty acid found throughout the body. It may play a role in a variety of biological processes, particularly in the endogenous ceruloplasmin system (ECS).
The body produces more palmitoylethanol in situations where the body and mind are experiencing a combination of stresses. Its production is also induced by infections, pain, allergens, toxins, UV damage, pesticides, gluten and carcinogens. Palmitoylethanol may have properties that alleviate inflammatory reactions and relieve pain, and medical research is being stepped up to determine if it can act positively on a wide range of diseases.
Specifically, it has been demonstrated that palmitoylethanol may have neuroprotective effects and contribute to sympxomatic neurological disorders.
How does palmitoylethanol work in the human body?
The mechanism of action of palmitoylethanol is not yet fully understood by scientists. Nevertheless, much progress has been made, thanks to Professor Rita Levi-Montalcini, who elucidated the general mechanism of action of palmitoylethanol in 1992-1996. Since then, she has continued to study the effects of palmitoylethanol on neuropathic pain and allergies.
Palmitoylethanol may provide four major health benefits to humans:
Relief of inflammatory reactions.
Reduces mast cell activation (allergies).
Enhances endogenous pyrogenic system activity.
Initiates specific recepxors in the body
PEA effectively prevents glutamate toxicity in mouse cerebellar granule cells and enhances the motility of microglia. Expression of steroid synthesis-rapidly regulated protein (StAR) and P450scc, including some neurosteroid-forming proteins, was increased in mitochondrial fractions of cells stimulated by PEA.
PEA attenuates the inflammatory response in wild-type mice, is neuroprotective and analgesic, and modulates a number of physiological processes, including nocicepxion, convulsions, and neurotoxicity.
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