Baohuoside I Powder 98%

Baohuoside I powder is a CXCR4 inhibitor that downregulates CXCR4 expression at 12-25 μM. Baohuoside I (0-25 μM) inhibited NF-κBactivation in a dose-dependent manner and suppressed CXCL12-induced invasion of cervical cancer cells. Baohuoside I also inhibited the invasion of breast cancer cells. Baohuoside I inhibited the viability of A549 cells with a CIC50sof25.1 μMat24h,11. Baohuoside I (25 μM) inhibited the asparaginase cascade, increased the ROS level and activated the JNK and p38MAPK signalling cascades in A549 cells. Baohuoside I (3.125, 6.25, 12.5, 25.0 and 50.0 µg/mL) significantly and dose-dependently blocked the growth of oesophageal squamous carcinoma Eca109 cells, with an IC50 of 4.8 µg/mL at 48 hours.

Baohuoside I Manufacturing Processing

Baohuoside powders are derived from Epimedium koreanum Nakai or Epimedium brevicornu Maxim, a herbal plant native to China, Asia. The Baohuoside manufacturing process begins with the raw material from the Epimedium plant being crushed and then extracted with ethanol. The extracted liquid is filtered and concentrated before diluting with water and undergoing enzymatic hydrolysis. Afterward, the substance is washed and parsed into ethanol, followed by concentration, solvent extraction, solvent recovery, crystallization, suction filtration, and drying which ultimately produces the Baohuoside powder 98% in its final powder form. Careful attention must be paid to each step during Baohuoside processing as their particular function helps create a product that can effectively retain its health benefits throughout its shelf life when stored properly. Ultimately Baohuoside manufacturing yields an important supplement with a range of positive effects on an individual's health when used correctly.

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At present, more than 379 compounds, including flavonoids, lignans, organic acids, terpenoids, dihydrophenanthrene derivatives, alkaloids and other components, have been detected in the leaves of the Chinese herb Epimedii Folium (EF). Among them, flavonoids such as dynorphin A, dynorphin B, dynorphin C, epimedoside, baohuoside I (also known as epimedoside II), epimedoside I, and epimedosin are recognised as the main chemical and pharmacologically active constituents.

Biosynthetic pathways of isoprenylated flavonoids in Epimedium vulgare

Researchers have studied and revealed the biosynthetic pathway of Icariinised flavonoids in Arrowleaf Epimedium and Pilose Epimedium. It can be divided into three stages (Figure 2): stage 1 is the phenylpropane synthesis pathway, stage 2 is the core pathway, and stage 3 is the side chain modification process. In stage 3, isopentenyl groups are added to flavonols by isopentenyltransferase (PT) and further modified by various postmodification enzymes such as UDP-glycosyltransferase (UGT) and O-methyltransferase (OMT) to produce a series of epimedium flavonoids, including chaotogonin A, chaotogonin B, chaotogonin C, epimedium glycoside, baobab glycoside I, epimedium hypimedium glycoside I, and epimediumin.

Biotransformation of Epimedium flavonoids by enzymes

Epimedium flavonoids mainly include chaotropidine A, chaotropidine B, chaotropidine C, epimedium glycoside, baohuoside I and epimedin. These compounds have similar structures to the glycoside Icariin, differing only in the type and number of sugar groups at the C-3 or C-7 positions. Icariin and Baohuoside I are considered to be the most potent constituents, but the content of Icariin and Baohuoside I in the Epimedium plant is very low.

Founded in 2014, Sanyi Chemical has 300 to 350 employees. The company integrates production, sales and service. It focuses on plant extracts, active ingredient monomers, plant powders, natural fruit and vegetable powders, and is dedicated to plant extracts. It is a professional company in R&D and production. Strong technical force, annual output of 500 tonnes, product specifications and stable quality.